Basic Information
VIS ID
TVIS44014450
Fusion event
HTLV-1-DROSHA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
31497334/31497227 (Hg38)
End
31497334/31497227 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA5A
Target gene
DROSHA
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-760 ; hsa-mir-505-3p ; hsa-mir-30d-5p ; hsa-mir-30a-5p ; hsa-mir-4290 ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-6892-3p ; hsa-mir-6872-3p ; hsa-mir-8485 ; hsa-mir-4762-5p ; hsa-mir-216a-5p ; hsa-mir-6516-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-7156-3p ; hsa-mir-4660 ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-148a-5p
Nearest miRNA
hsa-mir-10397/Upstream/14341235; hsa-mir-103a-1/Downstream/438875;
Nearest TSS
ENST00000502646/Upstream/8144; ENST00000515409/Downstream/29099;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/302915, chr5-CpG: 42/Downstream/34776
Upstream sequence
TGACTGGGGTACGTGGCACCCAGCAGGCATCTGAGGGTAGAGCACATCCCTGGAGAAGCTGCGCAGTCCCATCAGGAGTGCAGAGAGGATAATGTGCCCT
Downstream sequence
TCAGTGATTGTACAGACTTGCAGGGGATCATCTTCTAATTCCCCCACTGGCAGACAACAACAGAGAGGCTTTCTGCAGATAAACCTGACCTAAGACTTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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