Basic Information
VIS ID
TVIS44014451
Fusion event
HTLV-1-GFOD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
13396966/13396734 (Hg38)
End
13396966/13396734 (Hg38)
Orient
+
Location type
Intronic
Target gene
GFOD1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-9-5p ; hsa-mir-215-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-mir-19b-3p ; hsa-mir-1276 ; hsa-mir-484 ; hsa-mir-100-5p
Nearest miRNA
hsa-mir-3691/Upstream/2956940; hsa-mir-10398/Downstream/2744822;
Nearest TSS
ENST00000381078/Upstream/68151; ENST00000446001/Downstream/11403;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/31017, chr6-CpG: 223/Downstream/89358
Upstream sequence
gggaggtaagcaccactcttacaagaaggaagcaggagatcagaatgggtcataggagctgtgtcctggaagcaagaggttggagggacttgagaaaggg
Downstream sequence
gtcatgagccaaggtatacaggcagcttctagaagctggaaaaggcaagggtatggattctttccagaagcttccagcaggaacacggccctgccagcac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate