Basic Information
VIS ID
TVIS44014460
Fusion event
HTLV-1-SWAP70 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
9773041/9751494 (Hg38)
End
9773041/9751494 (Hg38)
Orient
+
Location type
UTR3
Target gene
SWAP70
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-145-5p ; hsa-mir-23c ; hsa-mir-23a-3p ; hsa-mir-23b-3p ; hsa-mir-130a-5p ; hsa-mir-4637 ; hsa-mir-4445-5p ; hsa-mir-186-3p ; hsa-mir-4429 ; hsa-mir-320d ; hsa-mir-320c ; hsa-mir-320b ; hsa-mir-320a
Nearest miRNA
hsa-mir-210/Upstream/661115; hsa-let-7a-2/Downstream/756776;
Nearest TSS
ENST00000527297/Upstream/24599; ENST00000527406/Downstream/6670;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/86991, chr11-CpG: 72/Downstream/6723
Nearest cancer related gene
SWAP70(OG, No orient, 0)
Upstream sequence
TTATGAAATCAAGCCTTCTAACACTAGTTATAATTGAGAAGCAACAGTAACTCCGTGGACAGCAATCAAGCTTAAAATTGTAAATAAATATGGGGATAAT
Downstream sequence
TCAGTTGTTGCAAAAAAAGGGCAGAATTCAGTAGAATAAAGTCCTTTTCTCTTACAGGTATTAAATGAGGACAGAGAACCTCAGGTGTTCTTATGCTAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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