Basic Information
VIS ID
TVIS44014465
Fusion event
HTLV-1-chr16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
86032782/85999176 (Hg38)
End
86032782/85999176 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12128/Upstream/80760; hsa-mir-11401/Downstream/1835416;
Nearest TSS
ENST00000527434/Upstream/3277; ENST00000601250/Downstream/90350;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/25095, chr16-CpG: 71/Downstream/287393
Nearby gene
IRF8(+76571) ;
Nearest cancer related gene
IRF8(TSG, +76571) ;
Upstream sequence
GGGTCACTGAGGCTCCCATCTTTAAAGTCATTGCCAACTTCTCCTTCTCTCTCAACCTGACTGGATGTTACAAATTCCTGTGTCATTTCCATTCTATTTC
Downstream sequence
TTGCTTTCAATCTTTTCTTTCACTTTCAGCATCTCTGTTCAGACCCTTGTCTCTTCCTGGATCTATCTTCTGTAAACTCCAAAGCAGCCCTCACAACTCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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