Proximate region of VIS (GRCh38)VISEnhancerEnhancer/PromoterPromoterGene5917313959139477591588365913894959143635591233095912438359148224
Basic Information
VIS ID
TVIS44014466
Fusion event
HTLV-1-SEC11C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
56815456/59148224 (Hg38)
End
56815456/59148224 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
SEC11C
miRNAs that regulate target gene
hsa-mir-30a-5p ; hsa-mir-1-3p
Nearest miRNA
hsa-mir-1-2/Upstream/697066; hsa-mir-5011/Downstream/7933360;
Nearest TSS
ENST00000575820/Upstream/8325; ENST00000591406/Downstream/7381;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/8031, chr18-CpG: 57/Downstream/71635
Upstream sequence
ggcccaggaattgagacagcacagtgttgatggaccacccacctggctctgcagatcaccccaacaactgcaggattgtgaagaggaagattgaggcagg
Downstream sequence
taccaaagtAAGGAGCCTCCCTGGAGGGCGGTGCTGGCAATGCCGTGAGGGGCTTTGATTTTGAGTGGTGCTAGCCACAGCAGCGTTAGTCCCTCTTGCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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