Basic Information
VIS ID
TVIS44014479
Fusion event
HTLV-1-ROS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
117708863/117387700 (Hg38)
End
117708863/117387700 (Hg38)
Orient
+
Location type
Intronic
Target gene
ROS1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-33a-5p ; hsa-mir-300
Nearest miRNA
hsa-mir-10398/Upstream/10603480; hsa-mir-1202/Downstream/1681347;
Nearest TSS
ENST00000381078/Upstream/50360; ENST00000533950/Downstream/38155;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/116584, chr6-CpG: 113/Downstream/94634
Nearest cancer related gene
ROS1(OG, No orient, 0)
Upstream sequence
TGCTTTCCTAATCTCAGAAAATAAATATGTACTCAATATGTGTTTACTCAAACACATACTCAAGAGGTCAATACACCCTCATTCTCATTTCTTTAAACCC
Downstream sequence
AAGGCAAGGAAATTTAAAGGGCACTCAGCTAGTCCTCTTTTTGTGAGAGTCACTCCCTAAATCCAGAACATTTTCTCACCTGGCACCAGGGTAGTACCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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