Basic Information
VIS ID
TVIS44014482
Fusion event
HTLV-1-ST7-AS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
116755769/117115715 (Hg38)
End
116755769/117115715 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA7G
Target gene
ST7-AS2
Nearest miRNA
hsa-mir-10525/Upstream/95396; hsa-mir-10399/Downstream/9942373;
Nearest TSS
ENST00000635602/Upstream/15953; ENST00000489293/Downstream/3971;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/161444, chr7-CpG: 143/Downstream/207072
Upstream sequence
agtgttgcgattacaggcatgagccaccgcgcccagccGGTAGGTTACTTTTTAAAGGCAGAATGGACTTGGGATCATGTCTCTGGGTAATTTGTActct
Downstream sequence
ttcccaccatcagtttctctctttccactggatttttttcccctaacacaaacatgtgtgaacctctctttttcataaaaaacaaaaTGAACACAAAACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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