Basic Information
VIS ID
TVIS44014489
Fusion event
HTLV-1-N6AMT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
29928217/28555895 (Hg38)
End
29928217/28555895 (Hg38)
Orient
-
Location type
Intronic
Target gene
N6AMT1
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-99a-5p ; hsa-mir-183-3p ; hsa-mir-3120-5p ; hsa-mir-20b-3p ; hsa-mir-4680-3p ; hsa-mir-5187-3p ; hsa-mir-4427 ; hsa-mir-5699-3p ; hsa-mir-4421 ; hsa-mir-6748-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929
Nearest miRNA
hsa-let-7c/Upstream/1601852; hsa-mir-3197/Downstream/1819399;
Nearest TSS
ENST00000624081/Upstream/16577; ENST00000399973/Downstream/70709;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/1411908, chr21-CpG: 29/Downstream/329208
Nearby gene
LINC00161(+15540) ;
Upstream sequence
acagcacaaaaatgctgaaaatcccaaaagccagaatgcctcttttcctccaaatcatcacaacacttctccagcaagggcactaaatagggctgaagct
Downstream sequence
gagatggatgaactgacagaagtggcttcagaaagggggtaataataaatttcactaagctaaagtattatgttctaacccaatgtaaggaagctaagaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate