Basic Information
VIS ID
TVIS44014494
Fusion event
HTLV-1-IL12RB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
67793958/67328275 (Hg38)
End
67793958/67328275 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA1L
Target gene
IL12RB2
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-625-5p ; hsa-mir-3180-5p ; hsa-mir-493-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-200b-5p ; hsa-mir-200a-5p ; hsa-mir-129-5p ; hsa-mir-6513-5p ; hsa-mir-887-5p ; hsa-mir-3913-5p ; hsa-mir-3122 ; hsa-mir-450a-1-3p ; hsa-mir-151a-3p
Nearest miRNA
hsa-mir-101-1/Upstream/699758; hsa-mir-11399/Downstream/855243;
Nearest TSS
ENST00000473358/Upstream/1506; ENST00000465396/Downstream/51653;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/193243, chr1-CpG: 139/Downstream/101177
Upstream sequence
CACGTGGTTGTGTTTTGTTTACAGGCTAAGTGGACCAAAAAATTTAACCTGGCAGAAGCAATGTAAAGACATTTATTGTGACTATTTGGACTTTGGAATC
Downstream sequence
AACCTCACCCCTGAATCACCTGAATCCAATTTCACAGCCAAGGTTACTGCTGTCAATAGTCTTGGAAGCTCCTCTTCACTTCCATCCACATTCACATTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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