Basic Information
VIS ID
TVIS44014499
Fusion event
HTLV-1-SRGAP2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
144008786/145000313 (Hg38)
End
144008786/145000313 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1F
Target gene
SRGAP2B
Nearest miRNA
hsa-mir-101-1/Upstream/27905585; hsa-mir-1182/Downstream/850274;
Nearest TSS
ENST00000473358/Upstream/44867; ENST00000400889/Downstream/92933;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/116278, chr1-CpG: 264/Downstream/92673
Nearby gene
FAM72C(No orient, 95626)
Upstream sequence
ATTGAGACCCTTCAGCATCTTTCTAAAAAGGAAATAAGCCTCTTTCTAAATACTAGGACGAGTATAGTTAGTGTCTCAGCTGTGGCCAAGCATGGGCAAG
Downstream sequence
GAGGCAGCATTTCCCAGGGGAAGCTTCATGGGTGTGTCTGGTGATGCTGGATTTGAATTCACATATAAAAACACTCCCTGGCAGGTCTTTATCTGACATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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