Basic Information
VIS ID
TVIS44014502
Fusion event
HTLV-1-ASPM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q31.3
Reference genome
GRCh37/hg19
Start
197096872/197127742 (Hg38)
End
197096872/197127742 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1K
Target gene
ASPM
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-let-7a-5p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-101-1/Upstream/545261; hsa-mir-1182/Downstream/1731131;
Nearest TSS
ENST00000473358/Upstream/60475; ENST00000475659/Downstream/7402;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/249454, chr1-CpG: 59/Downstream/18406
Upstream sequence
GCTATCCATCATACATACCAAAGCCAATTTTGAGCATTCCAGTTTGTTATTGAGGAAATATTGTGTAAtttgaagtcagatttcatgagtttatgtctca
Downstream sequence
attccactgtggaaaacttgggcaatctattctaccacttcatcttattttcctcatatgtaaaacaaggttaatactactaAAAATGGTCTCAAATGAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate