Basic Information
VIS ID
TVIS44014505
Fusion event
HTLV-1-PTER integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
16485300/16443301 (Hg38)
End
16485300/16443301 (Hg38)
Orient
+
Location type
Intronic
Target gene
PTER
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-29c-5p
Nearest miRNA
hsa-mir-1265/Upstream/2006640; hsa-mir-107/Downstream/1401806;
Nearest TSS
ENST00000439456/Upstream/6317; ENST00000485788/Downstream/41034;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/5997, chr10-CpG: 195/Downstream/76304
Upstream sequence
ggtctctctctttggcttgtggatggccgtcttcccttttatgcatgtctgggtattgatcttttatagggacaccagtcctattggattgagacctacc
Downstream sequence
ctaacaacccccttttaacttaattacttctgtaaagactatctgcaaatacaaccacatcctaaggtgctgagggttcgggctgcaacagacaaatttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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