Basic Information
VIS ID
TVIS44014521
Fusion event
HTLV-1-CNIH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
66048725/66281254 (Hg38)
End
66048725/66281254 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
CNIH2
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-10392/Upstream/632001; hsa-let-7a-2/Downstream/653180;
Nearest TSS
ENST00000527297/Upstream/2729; ENST00000531936/Downstream/1340;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2519, chr11-CpG: 41/Downstream/1025
Upstream sequence
ctcctcactcagaccaccatcagccctgcccctaaccctccaaaccgtccccttgctggtctGGCCTGagtatgacacagtggttaggaattttaactct
Downstream sequence
ggagtcacactgggttagaatccactaaccagccgtgtggccctggacaagtcacttaacctgcctcagcttcctcatctgcaaaacagacatgaaaata
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate