Basic Information
VIS ID
TVIS44014525
Fusion event
HTLV-1-CBL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
119113142/119242432 (Hg38)
End
119113142/119242432 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
CBL
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-mir-150-5p ; hsa-mir-155-5p ; hsa-mir-98-5p ; hsa-mir-188-3p ; hsa-mir-218-5p ; hsa-mir-1273d ; hsa-mir-7973 ; hsa-mir-6846-3p ; hsa-mir-6859-3p ; hsa-mir-4287 ; hsa-mir-4685-3p ; hsa-mir-1224-3p ; hsa-mir-1306-5p ; hsa-mir-216a-5p ; hsa-mir-124-3p ; hsa-mir-1972 ; hsa-mir-3150b-3p ; hsa-mir-4524a-3p ; hsa-mir-4524b-3p ; hsa-mir-4693-3p ; hsa-mir-4717-5p ; hsa-mir-4784 ; hsa-mir-5192 ; hsa-mir-6894-5p ; hsa-mir-7154-3p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-10392/Upstream/331645; hsa-let-7a-2/Downstream/70518;
Nearest TSS
ENST00000527297/Upstream/36008; ENST00000634301/Downstream/55940;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/35588, chr11-CpG: 19/Downstream/68254
Nearest cancer related gene
CBL(OG, No orient, 0)
Upstream sequence
ggagttcgagaccagcgtgaacatggtgaaaccccctcccttctaaaaatacaaaatcagctgggcatggtggcgggtacctgtaatccaagctactcag
Downstream sequence
gaggctgaggcaggagaattacttgaacccaggaggcggaggttgcagtgagccaagattgcaccactgcactctagcctgagtgacagagtgagactcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate