Basic Information
VIS ID
TVIS44014553
Fusion event
HTLV-1-ISM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
77960763/77494420 (Hg38)
End
77960763/77494420 (Hg38)
Orient
-
Location type
Intronic
Target gene
ISM2
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-92a-3p
Nearest miRNA
hsa-mir-1260a/Upstream/228130; hsa-mir-1185-1/Downstream/16453806;
Nearest TSS
ENST00000550708/Upstream/11521; ENST00000554074/Downstream/4246;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/18447, chr14-CpG: 144/Downstream/3808
Upstream sequence
TAGATTCAGGGGTTTGATGTTCTTTAGCTTCTTCATTAAGGTCTTTGGGCTGGTCAGTTAtttcttttttatttttcaattttttttaatttttgagatg
Downstream sequence
gagactcactctgtctcccaggctggagtgcagtggcacaatctcggctcactatgacctctgcctcctaggttcaagcaattcttctgcctcagcctcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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