Basic Information
VIS ID
TVIS44014561
Fusion event
HTLV-1-EVL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
100516111/100049774 (Hg38)
End
100516111/100049774 (Hg38)
Orient
-
Location type
Intronic
Target gene
EVL
miRNAs that regulate target gene
hsa-mir-221-3p
Nearest miRNA
hsa-mir-1260a/Upstream/4911788; hsa-mir-1185-1/Downstream/59645;
Nearest TSS
ENST00000550708/Upstream/30198; ENST00000557023/Downstream/15504;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/77248, chr14-CpG: 21/Downstream/94295
Nearby gene
EVL(+15640) ;
Upstream sequence
gaaagtatacaactcagttgtttttagtatattcactgagttttgcaaccatcaccacaattaattttagaacatttttatcaccccaaaagtagattct
Downstream sequence
acccattagcagtcagtcctcagtctcccccagcctctcctcaccagccctaggcaaccccaatctacttttttctctatggatttgccccttttggatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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