Basic Information
VIS ID
TVIS44014580
Fusion event
HTLV-1-ADAT1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
75654960/75621062 (Hg38)
End
75654960/75621062 (Hg38)
Orient
-
Location type
Intronic
Target gene
ADAT1
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-5002-3p ; hsa-mir-8055 ; hsa-mir-4282 ; hsa-mir-3118 ; hsa-mir-134-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-4681 ; hsa-mir-4506 ; hsa-mir-129-5p ; hsa-mir-4524b-3p ; hsa-mir-6894-3p ; hsa-mir-5001-3p ; hsa-mir-378a-5p ; hsa-mir-4763-5p ; hsa-mir-6778-3p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-6747-3p ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4701-5p ; hsa-mir-588 ; hsa-mir-3119 ; hsa-mir-3190-5p ; hsa-mir-6771-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-4722-5p ; hsa-mir-6746-5p ; hsa-mir-4768-3p ; hsa-mir-5690
Nearest miRNA
hsa-mir-1225/Upstream/5590640; hsa-mir-11401/Downstream/1247874;
Nearest TSS
ENST00000527434/Upstream/12105; ENST00000569234/Downstream/1404;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/54100, chr16-CpG: 47/Downstream/1945
Upstream sequence
TACTATCTCCCTGCCCCCTTTTCATCTTTAATGAAAGATCAAAGAAACCCCAAATTCTACCAATCCCCAAAATTATTGTTTCAAGTTTTTCTTAATGTTA
Downstream sequence
TATATCTGATACATTTCTAAGGAGTCTGCATCCTCTACTCAACATTAAAGGACACGAGAAGGAAATGTCCTCACTACTCCAGTTTTCACTGGAAACGGCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate