Basic Information
VIS ID
TVIS44014582
Fusion event
HTLV-1-GSE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
85597370/85563764 (Hg38)
End
85597370/85563764 (Hg38)
Orient
+
Location type
Intronic
Target gene
GSE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-769-5p ; hsa-mir-331-3p ; hsa-mir-361-3p ; hsa-mir-324-3p ; hsa-mir-759 ; hsa-mir-1913 ; hsa-mir-5586-3p ; hsa-mir-548av-3p ; hsa-mir-513a-5p ; hsa-mir-5687 ; hsa-mir-4775 ; hsa-mir-4313 ; hsa-mir-1236-5p ; hsa-mir-29c-5p ; hsa-mir-4773 ; hsa-mir-548g-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-489-3p
Nearest miRNA
hsa-mir-12128/Upstream/257439; hsa-mir-11401/Downstream/177857;
Nearest TSS
ENST00000527434/Upstream/7797; ENST00000567093/Downstream/19807;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6752, chr16-CpG: 25/Downstream/22569
Nearby gene
GSE1(No orient, 47659)
Upstream sequence
AGGAAGCGCCCTCTGACCAGGCCTGGACCGCCGCCCAGTGGGCATTTGGCTGCTTGCTTAATGGCCTGTGGGGtcaggaagtcacggaacattggacttg
Downstream sequence
ggagggacctcagaggtcaGACGGGCTGTCCCTCCCTTCTCTGGATTTGGGGGTCTCGTGGTCACCTCAGGCTGGGCACGTGCAGGTCCTGCTCCTGGGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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