Basic Information
VIS ID
TVIS44014588
Fusion event
HTLV-1-SPAG9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
49091086/51013725 (Hg38)
End
49091086/51013725 (Hg38)
Orient
+
Location type
Intronic
Target gene
SPAG9
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-9-5p ; hsa-mir-122-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-877-3p ; hsa-mir-193b-3p ; hsa-mir-484 ; hsa-mir-27b-3p ; hsa-let-7e-5p ; hsa-mir-218-5p ; hsa-mir-578 ; hsa-mir-3611 ; hsa-mir-6818-3p ; hsa-mir-4753-3p ; hsa-mir-98-3p ; hsa-let-7f-1-3p ; hsa-let-7b-3p ; hsa-let-7a-3p ; hsa-mir-1257 ; hsa-mir-593-3p ; hsa-mir-6895-3p ; hsa-mir-581 ; hsa-mir-130b-5p ; hsa-mir-1284 ; hsa-mir-323b-3p ; hsa-mir-95-5p ; hsa-mir-4666a-3p ; hsa-mir-381-3p ; hsa-mir-300 ; hsa-mir-3529-3p ; hsa-mir-200a-3p ; hsa-mir-141-5p
Nearest miRNA
hsa-mir-10226/Upstream/244995; hsa-mir-1250/Downstream/5877545;
Nearest TSS
ENST00000595228/Upstream/11980; ENST00000509833/Downstream/2531;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/68807, chr17-CpG: 99/Downstream/106436
Nearest cancer related gene
SPAG9(OG, No orient, 0)
Upstream sequence
aattaaggtccaaaaaggttaagacacttggcaaaggtcagcaggcaaatagtctaagagcCAAATGCAATATTCTTTTCAGACCATGTATTCTTCTAGA
Downstream sequence
ACACAAACTTTAAAATGATTATATTTACCATAGGGCTAAAACATAATATACTCTGAGAAAACTTAGAAAAATCAAGTGTTATAATTTCTTATTTAATTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate