Basic Information
VIS ID
TVIS44014606
Fusion event
HTLV-1-KIRREL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
36351153/35860251 (Hg38)
End
36351153/35860251 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
KIRREL2
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-10395/Upstream/514624; hsa-let-7e/Downstream/3549372;
Nearest TSS
ENST00000633603/Upstream/3145; ENST00000589743/Downstream/7648;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/3052, chr19-CpG: 57/Downstream/287
Upstream sequence
ctgaaagcccagactcctggctcaaagggagaaggggattaggggcccagactcctgggatggaggaaccagggactggACACCTAGGCCAGTGACGGAG
Downstream sequence
GTGTTCCTGGTCCTTGCCCATCTGACCATTGTCCCACCCTCACAGACCCCCCAGAGGTGACTCTGTCTGCTTCGCCACACACTGTGCAGGAGGGAGAGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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