Basic Information
VIS ID
TVIS44014608
Fusion event
HTLV-1-TMEM18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
664738/664738 (Hg38)
End
664738/664738 (Hg38)
Orient
-
Location type
Intronic
Target gene
TMEM18
miRNAs that regulate target gene
hsa-mir-374a-3p ; hsa-mir-222-5p ; hsa-mir-361-5p ; hsa-mir-3129-5p ; hsa-mir-199b-3p ; hsa-mir-199a-3p ; hsa-mir-936 ; hsa-mir-5094 ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac
Nearest miRNA
hsa-mir-10b/Downstream/5309924;
Nearest TSS
ENST00000437798/Upstream/106534; ENST00000445418/Downstream/6237;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/3829, chr2-CpG: 90/Downstream/11913
Nearby gene
TMEM18(-3235) ;
Upstream sequence
GGATTTCAGGAAATATGTACAACCAATattggcatatgctttctgaaaattgatttagcaacatttaccaactgtcacataaaagttatatatgttgact
Downstream sequence
aaatttcacttgtaagaatttattccaagtcaatagtggaaatgtaggcatgtgaggttggagatttctgtgttgctgttgtcagtaaaacaattagaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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