Basic Information
VIS ID
TVIS44014611
Fusion event
HTLV-1-ALK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p23.2
Reference genome
GRCh37/hg19
Start
29982077/29759211 (Hg38)
End
29982077/29759211 (Hg38)
Orient
+
Location type
Intronic
Target gene
ALK
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-96-5p
Nearest miRNA
hsa-mir-1301/Upstream/1762762; hsa-mir-10b/Downstream/2772942;
Nearest TSS
ENST00000437798/Upstream/41511; ENST00000421411/Downstream/131160;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/643168, chr2-CpG: 147/Downstream/160754
Nearest cancer related gene
ALK(OG, No orient, 0)
Upstream sequence
TCAGTCTCTCCTCTTGTCTGAAGTTAACCAGTTGGAATGCAAGTCTGCAAGATGGTCACACAAGACCTTTTTCTTCATTATTGTACTTTCCTATTCCTTG
Downstream sequence
AGAATATTCATCATCTTTCACCTAACTGAGGTTTTCTGTCTGCCTTTCCGTTTAGTCAACTAAGTGGGCAAGTTAGCTAACTGTATGTTGGCTTGTATAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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