Basic Information
VIS ID
TVIS44014635
Fusion event
HTLV-1-TMEM50B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr21
Cytoband
q22.11
Reference genome
GRCh37/hg19
Start
34847950/33475643 (Hg38)
End
34847950/33475643 (Hg38)
Orient
+
Location type
Intronic
Target gene
TMEM50B
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-4474-5p ; hsa-mir-550a-3p ; hsa-mir-200c-5p ; hsa-mir-4261 ; hsa-mir-6134 ; hsa-mir-7854-3p ; hsa-mir-600 ; hsa-mir-154-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5692a
Nearest miRNA
hsa-let-7c/Upstream/3100265; hsa-mir-3197/Downstream/75019;
Nearest TSS
ENST00000624081/Upstream/6717; ENST00000475072/Downstream/3646;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/71456, chr21-CpG: 147/Downstream/3279
Upstream sequence
caccatcttggccaggctggtcttgaactcctgacctcgtgatccacccgccttggcctcccaaagtgctgggaatacaggcgtgagccaccgcgcccag
Downstream sequence
GAAGAAATTACTTTTAAAAAAGAACAAGCAgctgggtgcggtggcttactcctgtaatcccagcactttgggaggccaaggtgggcagatcatgaggtca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate