Basic Information
VIS ID
TVIS44014645
Fusion event
HTLV-1-TBC1D22A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.31
Reference genome
GRCh37/hg19
Start
47417640/47021744 (Hg38)
End
47417640/47021744 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
TBC1D22A
miRNAs that regulate target gene
hsa-mir-342-5p ; hsa-mir-484 ; hsa-mir-4633-5p ; hsa-mir-532-5p ; hsa-mir-499b-3p ; hsa-mir-499a-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7a-3/Upstream/907976; hsa-mir-12114/Downstream/1252620;
Nearest TSS
ENST00000624155/Upstream/105702; ENST00000434707/Downstream/323825;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/161216, chr22-CpG: 19/Downstream/6574
Upstream sequence
actctagcagaaccccacctgtagcctgggcccatagagactgtgacccatacagactcataaatatatgttgttttaagctgctaagtttatggtaatt
Downstream sequence
ggttacagagcaacagaaaactaataAAATGAACAAAGGACAAATAATCCCACAGAGTCCCTGTCTCCCTCCCGCCCCAGTGCTGGGGTTCAGGGCCTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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