Basic Information
VIS ID
TVIS44014648
Fusion event
HTLV-1-GOLGA4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
37361764/37320273 (Hg38)
End
37361764/37320273 (Hg38)
Orient
-
Location type
Intronic
Target gene
GOLGA4
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-21-5p ; hsa-mir-186-5p ; hsa-mir-450a-1-3p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-887-5p ; hsa-mir-1290 ; hsa-mir-3122 ; hsa-mir-3913-5p ; hsa-mir-4666a-5p ; hsa-mir-4769-3p ; hsa-mir-5089-5p ; hsa-mir-6513-5p ; hsa-mir-6728-5p ; hsa-mir-6817-5p ; hsa-mir-32-5p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-2681-5p ; hsa-mir-202-3p ; hsa-let-7g-5p ; hsa-let-7a-5p ; hsa-let-7b-5p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-12127/Upstream/1575714; hsa-let-7g/Downstream/649131;
Nearest TSS
ENST00000440867/Upstream/38090; ENST00000497537/Downstream/1316;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/76483, chr3-CpG: 135/Downstream/131654
Upstream sequence
AAGATTTTTTAAAATAGCATAATTTGAAAGTTTAAAACAAAAAATATTTTTCTTCACTTATGAAAGCCTTTTATATAAGTTGCCATAAAAAAGTGTTAGT
Downstream sequence
GACAAAAATGTAATTTGTTTTTGTATGAAATTATTATCCGTAAGATAATATGTGTAACTCAAAAATGCTTTCCGTGTAAAAGGATAATAAATAGTATTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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