Basic Information
VIS ID
TVIS44014657
Fusion event
HTLV-1-OSBPL11 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
125288688/125569844 (Hg38)
End
125288688/125569844 (Hg38)
Orient
+
Location type
Intronic
Target gene
OSBPL11
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-7-5p ; hsa-mir-615-3p
Nearest miRNA
hsa-let-7g/Upstream/418292; hsa-mir-12124/Downstream/220560;
Nearest TSS
ENST00000440867/Upstream/49647; ENST00000610060/Downstream/25246;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/49487, chr3-CpG: 54/Downstream/25298
Upstream sequence
aaaaggaacagttacactcaacatcctaagtaaatctcaaacacatacagtgaactgaaaagcagccatacccgaaggagtacatactatatgattccag
Downstream sequence
ttttagaagcatcaaaaataggcaaaataaatctatggtgttcaggatagtgaggaagggtgttgtgatgaggggcacagaagtggccctagggtgctcg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate