Basic Information
VIS ID
TVIS44014664
Fusion event
HTLV-1-DGKG integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q27.3
Reference genome
GRCh37/hg19
Start
186034530/186316741 (Hg38)
End
186034530/186316741 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3C
Target gene
DGKG
miRNAs that regulate target gene
hsa-mir-6083 ; hsa-mir-5011-5p ; hsa-mir-190a-3p ; hsa-mir-410-3p ; hsa-mir-1277-5p ; hsa-mir-1295b-3p ; hsa-mir-4789-5p ; hsa-mir-8485 ; hsa-mir-499a-5p ; hsa-mir-208b-3p ; hsa-mir-208a-3p
Nearest miRNA
hsa-let-7g/Upstream/548837; hsa-mir-1248/Downstream/469931;
Nearest TSS
ENST00000440867/Upstream/35482; ENST00000421006/Downstream/3747;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/122302, chr3-CpG: 94/Downstream/44180
Upstream sequence
AAGTTACTTGTCTCCAAGAGCAGTTTTAAGATGCCCCACCCTCACCCTATAGAAGGTCACCAGAGAAGGTGCCAACTTTACACTATATAAATGGAAAACA
Downstream sequence
ACAAGAGCCTCTCCTACCTGGTAACCCCACTGGAGAAAGTTCTCAATTCTCAGGCTGTACACTTCATTATTTTGTTATTGTAAAGCTCCTGTTTATGTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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