Basic Information
VIS ID
TVIS44014671
Fusion event
HTLV-1-BANK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
102943258/102022101 (Hg38)
End
102943258/102022101 (Hg38)
Orient
+
Location type
Intronic
Target gene
BANK1
miRNAs that regulate target gene
hsa-mir-7641 ; hsa-mir-4662a-5p ; hsa-mir-590-3p ; hsa-mir-6768-3p
Nearest miRNA
hsa-mir-12113/Upstream/691687; hsa-mir-1243/Downstream/7466597;
Nearest TSS
ENST00000502981/Upstream/40238; ENST00000504403/Downstream/14802;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/231059, chr4-CpG: 100/Downstream/322369
Upstream sequence
tctacattcTAATGTCTGAAGAATAATTCAGGATGTTCCtacatgtatataaacgtatatgtgtatataaatgtatatatatacacatatatacatgtat
Downstream sequence
atataaacgtgtatatataCGCGTTTATATGTGTACGTAAACTCCACCCATTATGCCAGGCTTTATTGGCATACAGctcaacagcttcaccagcatgttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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