Basic Information
VIS ID
TVIS44014675
Fusion event
HTLV-1-INPP4B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q31.21
Reference genome
GRCh37/hg19
Start
143187823/142266670 (Hg38)
End
143187823/142266670 (Hg38)
Orient
-
Location type
Intronic
Target gene
INPP4B
miRNAs that regulate target gene
hsa-mir-222-3p ; hsa-mir-181a-5p ; hsa-mir-765
Nearest miRNA
hsa-mir-12113/Upstream/16759363; hsa-mir-1305/Downstream/1076790;
Nearest TSS
ENST00000502981/Upstream/544888; ENST00000514766/Downstream/39162;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/629500, chr4-CpG: 111/Downstream/579117
Nearest cancer related gene
INPP4B(TSG, No orient, 0)
Upstream sequence
GACACTAAACCAGAAAATAAGTCACAATGGGCCTTAATTTTTTAATGTTCATTTATaaagcttttcttctacaatcaagaacaagacaaagatgtccatt
Downstream sequence
ctcaccacttctattcaatgttatactgaaagttctagctggaacaatcagacaagaaaaagaaataaaagatatccaaataggaaaggaagaagggaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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