Basic Information
VIS ID
TVIS44014685
Fusion event
HTLV-1-FRG1-DT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
190825675/189904520 (Hg38)
End
190825675/189904520 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRG1-DT
Nearest miRNA
hsa-mir-12113/Upstream/4966080;
Nearest TSS
ENST00000502981/Upstream/23005; ENST00000533157/Downstream/12802;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/57343, chr4-CpG: 91/Downstream/35916
Nearby gene
LINC01596(No orient, 19653)
Upstream sequence
TGCTAAAAGATTATGTTTGTACATGAAAAATTTTACACATTCTTTCTATGAGATAAACCTGATAACACCTTGAAAACTTAATAGTTATGGAAAAGGAACT
Downstream sequence
ACTGTGATATTTTTTAGAGAATGTCGTGTTCTTGATGTTCTTGAGTGAGCTGTCTCATGTTATTAGAAGGGAAACAGCACCACCTTGTGGGGAAACAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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