Basic Information
VIS ID
TVIS44014688
Fusion event
HTLV-1-MTRR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
7873774/7873661 (Hg38)
End
7873774/7873661 (Hg38)
Orient
+
Location type
Intronic
Target gene
MTRR
miRNAs that regulate target gene
hsa-let-7b-5p ; hsa-mir-19b-3p
Nearest miRNA
hsa-mir-4277/Upstream/1045740; hsa-mir-10397/Downstream/587264;
Nearest TSS
ENST00000502646/Upstream/2891; ENST00000508890/Downstream/1501;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3934, chr5-CpG: 88/Downstream/583658
Upstream sequence
ACTATTGATATCTCTGGTATCTGAATTATCTTTCAGAACTATGAAGTGTGATCATATAGGTTTTGTCTTTCTtatgtaaatattatgtatatgtatatat
Downstream sequence
aaatgtatgtAATGTGCTACCTTTTCTGAATCTTCCCCAGACTTTACCCCAGAGCCACACCTCTGCAGAACCTCTTGAGTAGCATTTTAATTAAGGATGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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