Basic Information
VIS ID
TVIS44014697
Fusion event
HTLV-1-DNAJC18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
138769584/139433895 (Hg38)
End
138769584/139433895 (Hg38)
Orient
-
Location type
Intronic
Target gene
DNAJC18
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-4701-5p ; hsa-mir-4715-3p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-1227-3p ; hsa-mir-365b-5p ; hsa-mir-365a-5p ; hsa-mir-8052 ; hsa-mir-3199 ; hsa-mir-6778-3p ; hsa-mir-4740-3p ; hsa-mir-455-5p ; hsa-mir-4438
Nearest miRNA
hsa-mir-10397/Upstream/1786246; hsa-mir-103a-1/Downstream/1129776;
Nearest TSS
ENST00000502646/Upstream/7666; ENST00000637503/Downstream/3665;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/29672, chr5-CpG: 48/Downstream/83980
Upstream sequence
gataaaatagactagaatctagatatattttatgcattcatataattttcttaattttttggtatgtccatgctccatggtttgtgagatggtgatgatg
Downstream sequence
atgattattatttgagacagagtttcgctcttgttgcccaggctggagtgcaatggcacaatcacagctcactgcaacctctgccttctgggttcaaaca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate