Basic Information
VIS ID
TVIS44014712
Fusion event
HTLV-1-UTRN integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
144819708/144498572 (Hg38)
End
144819708/144498572 (Hg38)
Orient
-
Location type
Intronic
Target gene
UTRN
miRNAs that regulate target gene
hsa-mir-206 ; hsa-mir-1-3p ; hsa-mir-21-5p ; hsa-mir-455-3p ; hsa-mir-505-3p ; hsa-mir-484 ; hsa-mir-331-3p ; hsa-let-7b-5p ; hsa-mir-3136-3p ; hsa-mir-4313 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-1915-5p ; hsa-mir-6793-3p ; hsa-mir-4714-3p ; hsa-mir-203b-5p ; hsa-mir-3691-3p ; hsa-mir-556-3p ; hsa-mir-6718-5p ; hsa-mir-6801-5p
Nearest miRNA
hsa-mir-10398/Upstream/3814689; hsa-mir-1202/Downstream/6604103;
Nearest TSS
ENST00000381078/Upstream/154471; ENST00000367525/Downstream/84638;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/211428, chr6-CpG: 132/Downstream/1236188
Upstream sequence
TAATTATAAAACATATAATTGTGAAAATGGTGCTATTTTCCCCTCAAGTTACTATAATACCGTATTTTTCCTTCATGGAGAGGATTCTAAGATATCTTAT
Downstream sequence
GTTCAAAATTATAATAGATACTAGTGATTTTTCAACTTTATTTCTGCCCTTTTATGTGTGTTTTTCTCGCTTAATACACATAACAATCtttttttttttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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