Basic Information
VIS ID
TVIS44014724
Fusion event
HTLV-1-PTK2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
27230944/27373427 (Hg38)
End
27230944/27373427 (Hg38)
Orient
-
Location type
Intronic
Target gene
PTK2B
miRNAs that regulate target gene
hsa-mir-23b-3p ; hsa-mir-335-5p ; hsa-mir-517c-3p ; hsa-mir-517a-3p ; hsa-mir-4736 ; hsa-mir-3665 ; hsa-mir-4514 ; hsa-mir-4692 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p
Nearest miRNA
hsa-mir-124-1/Upstream/324464; hsa-mir-10400/Downstream/59943;
Nearest TSS
ENST00000518652/Upstream/46604; ENST00000496920/Downstream/7224;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/47554, chr8-CpG: 29/Downstream/89970
Nearest cancer related gene
PTK2B(OG, No orient, 0)
Upstream sequence
TCTAAAGTGTTCTCCCTGACCAGAGTCTTCACATAGTTCTTTGCCTGGGGAGGGGACTTGGGTAGTGGTGGGAAAACTCTTCCCCCTCCAACTAGAAAGT
Downstream sequence
AGCTAAACAACTGGAGAGAATTGGCCTTGGGCAAGCAGCTAGGAGAGGACCCGTTGCTCCTCCCTGCCTCTATATTGTGTAAGTTTATCCCGACATTTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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