Basic Information
VIS ID
TVIS44014736
Fusion event
HTLV-1-VPS13A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
79949292/77334376 (Hg38)
End
79949292/77334376 (Hg38)
Orient
+
Location type
Intronic
Target gene
VPS13A
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-15b-5p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-7111-3p ; hsa-mir-4326 ; hsa-mir-6502-5p ; hsa-mir-1301-5p ; hsa-mir-138-2-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6524292; hsa-let-7a-1/Downstream/6635372;
Nearest TSS
ENST00000422679/Upstream/15855; ENST00000539950/Downstream/5825;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/155964, chr9-CpG: 108/Downstream/313154
Upstream sequence
TCCATTTTTATAAATTTTATCTCCATCTATTAGTTTGATCTGTTTTTTTCTTCTTGTCTCAGATAATTTGATGTTCTGTTTCAAGACCATTCACACTACC
Downstream sequence
ATATCTTCTCATTTAAAACCTCCTGTCATTGATTATCTTTCTTTCCTGTTTTCCTTATTCATTCCTTGAACTTTCCTTTGACGTTTTATATTTCTCTTAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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