Basic Information
VIS ID
TVIS44014742
Fusion event
HTLV-1-RALGPS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q33.3
Reference genome
GRCh37/hg19
Start
129924723/127162444 (Hg38)
End
129924723/127162444 (Hg38)
Orient
+
Location type
Intronic
Target gene
RALGPS1
miRNAs that regulate target gene
hsa-mir-377-3p ; hsa-mir-342-3p ; hsa-mir-3120-3p ; hsa-mir-8485
Nearest miRNA
hsa-let-7a-1/Upstream/2468646; hsa-mir-12126/Downstream/528243;
Nearest TSS
ENST00000422679/Upstream/39561; ENST00000467325/Downstream/48059;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/246714, chr9-CpG: 161/Downstream/61841
Upstream sequence
TGGTACAAGTGGAAGGTGGTTATTCTTACGATTTCATTATAGTTTAGGCTTATACATATCTCTGTTGTGGACTAATACAGTACTGAAAAGATTTCTGTGG
Downstream sequence
ATTTGTGCAGCGTTAACTGTAGGAGACTTGCTGCTTGTGCTGTGGTTTTCATTGTGGGAGTGAAAGGCTGTTTATAGGGAAGTTCTTTCTAGGCATTGCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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