Basic Information
VIS ID
TVIS44014743
Fusion event
HTLV-1-GLE1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q34.11
Reference genome
GRCh37/hg19
Start
131271171/128508892 (Hg38)
End
131271171/128508892 (Hg38)
Orient
+
Location type
Exonic
Target gene
GLE1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-33a-5p
Nearest miRNA
hsa-let-7a-1/Upstream/116178; hsa-mir-12126/Downstream/1360713;
Nearest TSS
ENST00000422679/Upstream/4161; ENST00000494417/Downstream/14756;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/3894, chr9-CpG: 126/Downstream/43057
Upstream sequence
TTAGATGTTCAGTAAGGCATGTAGTGGATTATACTGAGAACAGTTGACGTGTAAGTTGAGCTTAACCCTATTCTTTTCTCTAGGATGTTTTAGAAGAATG
Downstream sequence
TATGTCTCTTCCCAAGCTATCTTCTTATTCTGGATGGGTGGTAGAGCACGTCCTACCCCATATGCAGGAGAACCAACCTCTGTCTGAGACTTCGCCATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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