Basic Information
VIS ID
TVIS44014746
Fusion event
HTLV-1-UBA1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p11.3
Reference genome
GRCh37/hg19
Start
47050696/47191297 (Hg38)
End
47050696/47191297 (Hg38)
Orient
+
Location type
Intronic
Target gene
UBA1
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-1301-3p ; hsa-mir-744-5p ; hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-331-3p ; hsa-mir-27b-3p ; hsa-mir-222-3p ; hsa-mir-210-3p ; hsa-mir-182-5p ; hsa-mir-17-3p ; hsa-let-7b-5p ; hsa-mir-6834-5p ; hsa-mir-4278 ; hsa-mir-5010-5p ; hsa-mir-5187-5p ; hsa-mir-4525 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-6875-5p ; hsa-mir-3126-5p ; hsa-mir-1272 ; hsa-mir-6732-5p ; hsa-mir-6805-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6822-5p ; hsa-mir-6750-5p ; hsa-mir-3591-3p ; hsa-mir-21-3p
Nearest miRNA
hsa-mir-1587/Upstream/1444173; hsa-let-7f-2/Downstream/396132;
Nearest TSS
ENST00000429181/Upstream/436; ENST00000457753/Downstream/102;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/356, chrX-CpG: 46/Downstream/2407
Upstream sequence
AGGGTCCGTGTATGGGCACCCTTGTCCGTGGAGCAGGATTTGGGTTATTCTTCAAGGGGAGAAGCAAAGCTTGAGGTTACTAAAGTCAAGGCGGGACTGG
Downstream sequence
GGGAGGGCTTGTTTCAGGACGGGGTCCTGGTGACAGAACAATCGGGACCGACGTGGCATTGTGGAGGTGTCAGGCCTTTGTGACCTCTGGTTTTGTGATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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