Basic Information
VIS ID
TVIS44014753
Fusion event
HTLV-1-SH3D21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
36785105/36319504 (Hg38)
End
36785105/36319504 (Hg38)
Orient
+
Location type
Exonic
Target gene
SH3D21
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-12136/Upstream/1649810; hsa-mir-101-1/Downstream/842059;
Nearest TSS
ENST00000473358/Upstream/248; ENST00000474766/Downstream/536;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/12096, chr1-CpG: 232/Downstream/1395
Upstream sequence
AGAGTAGGCTTGGGTCCCTGAGGTTCTGCTCTCTTAGGCCCCAATGGTGGCTTCCAAAGTGGGGGTTCGTATCACCCTGGCCGAAAGCGATCCAAAACCC
Downstream sequence
AGACTCCCCAGCAACGCTCTGTGTCCAGTCAGGTGAGGGGCGGGAGACATGGGAGAGTGGGGATGCTGGGCAGAGGCTGGTTCCCAGCTGTGGTGTGCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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