Basic Information
VIS ID
TVIS44014755
Fusion event
HTLV-1-HELLS integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q23.33
Reference genome
GRCh37/hg19
Start
96373425/94613668 (Hg38)
End
96373425/94613668 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D
Target gene
HELLS
miRNAs that regulate target gene
hsa-mir-7-5p ; hsa-mir-193b-3p ; hsa-mir-124-3p ; hsa-let-7b-5p ; hsa-mir-877-3p ; hsa-mir-769-5p ; hsa-mir-615-3p ; hsa-mir-607 ; hsa-mir-6895-3p ; hsa-mir-138-2-3p ; hsa-mir-205-3p
Nearest miRNA
hsa-mir-107/Upstream/5020841; hsa-mir-1287/Downstream/1450647;
Nearest TSS
ENST00000439456/Upstream/16788; ENST00000339022/Downstream/69953;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/67532, chr10-CpG: 63/Downstream/569770
Nearby gene
HELLS(+11569) ;
Upstream sequence
tttgactggtactgttttcattgttatttaattttgtgttttttaacttctttcatgatttccttttaactgaaggttttcttagatatttagtttgctg
Downstream sequence
gtatattcttttaaaattgtatcattgctttctttctatattggattattgtcagagaacatgatttgcatgatattaactttttggagtatattgttgc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate