Basic Information
VIS ID
TVIS44014756
Fusion event
HTLV-1-CD82 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
44596738/44575188 (Hg38)
End
44596738/44575188 (Hg38)
Orient
+
Location type
Intronic
Target gene
CD82
miRNAs that regulate target gene
hsa-mir-362-3p ; hsa-mir-197-3p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-6888-3p ; hsa-mir-4753-3p ; hsa-mir-4294 ; hsa-mir-130b-5p ; hsa-mir-1470 ; hsa-mir-4667-3p ; hsa-mir-6793-3p
Nearest miRNA
hsa-mir-129-2/Upstream/993705; hsa-let-7a-2/Downstream/1116516;
Nearest TSS
ENST00000527297/Upstream/2110; ENST00000529853/Downstream/12044;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/9351, chr11-CpG: 125/Downstream/151779
Nearest cancer related gene
CD82(TSG, No orient, 0)
Upstream sequence
GTTTCGCTTCAGCCCTACTGGTGGGGGAGCGTTCTGTCTGTCCCTGGTGCTAGTTGGCCTACCCACAGGAGGAGGAGGAGCAGGCTTTTAGGGTATGTGT
Downstream sequence
ATCTGTGAAAGAGAAGGAGATGGAGAAAGGCAGATAGATATAGGGGAGTGTTTTCTCTTCAATTACAGTCTGATTTTGACCCTCTCCTCTCTGGGAGCCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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