Basic Information
VIS ID
TVIS44014794
Fusion event
HTLV-1-EHD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
64636174/64868702 (Hg38)
End
64636174/64868702 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11H
Target gene
EHD1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-34a-5p ; hsa-mir-7-5p ; hsa-mir-6739-5p ; hsa-mir-670-5p ; hsa-mir-6733-5p ; hsa-mir-3153 ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-4329 ; hsa-mir-6859-3p ; hsa-mir-7113-3p ; hsa-mir-4324 ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-4732-3p ; hsa-mir-125a-5p ; hsa-mir-345-3p ; hsa-mir-645 ; hsa-mir-1226-3p ; hsa-mir-26b-5p ; hsa-mir-19b-3p ; hsa-mir-26a-5p ; hsa-mir-19a-3p
Nearest miRNA
hsa-mir-1237/Upstream/499999; hsa-let-7a-2/Downstream/9821;
Nearest TSS
ENST00000527297/Upstream/8657; ENST00000413292/Downstream/6964;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/13928, chr11-CpG: 124/Downstream/9255
Upstream sequence
gacattccggaaaaggcaaaagttagagacaaaggtcagtgggctgcctgggaccaggagtgactatgaggggcacgggaactttcaggcgatgggaata
Downstream sequence
ctctctgtcatggtggcggCAGCCCAGGAATGCTTTGTACAGCAGGGCACCTGAGGAGGGTGGACTTCACTACACACAACGTAGACCCCAGCAAATCAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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