Basic Information
VIS ID
TVIS44014800
Fusion event
HTLV-1-KCNMB4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q15
Reference genome
GRCh37/hg19
Start
70763993/70370213 (Hg38)
End
70763993/70370213 (Hg38)
Orient
-
Location type
Intronic
Target gene
KCNMB4
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-335-3p ; hsa-mir-1305 ; hsa-mir-6826-3p ; hsa-mir-190a-3p ; hsa-mir-6832-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-3074-3p ; hsa-mir-5011-5p ; hsa-mir-421 ; hsa-mir-7159-5p ; hsa-mir-505-3p ; hsa-mir-4446-5p ; hsa-mir-3201 ; hsa-mir-4791 ; hsa-mir-190b ; hsa-mir-190a-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4307
Nearest miRNA
hsa-let-7i/Upstream/785390; hsa-mir-1178/Downstream/9049044;
Nearest TSS
ENST00000382841/Upstream/3937; ENST00000531884/Downstream/29997;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2941, chr12-CpG: 52/Downstream/239631
Upstream sequence
cattgatgttttttaaaagttctgtgatgattctaatgtgaagacaagattcaaaaaccactgTCTTAGAAAATGTTCTCATCTGCTGTGCAAGAAAAAC
Downstream sequence
AACCTGAGAACCAAAAAGGAGTCATTGTGATTAATATTTGTGTTTTCAGATTAAAAGATATTGTTGGTGCTACTGAAttttttgtttttttttgtttttt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate