Basic Information
VIS ID
TVIS44014804
Fusion event
HTLV-1-ZMYM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q12.11
Reference genome
GRCh37/hg19
Start
20624191/20050051 (Hg38)
End
20624191/20050051 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZMYM2
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-1229-3p ; hsa-mir-23b-3p ; hsa-let-7b-5p ; hsa-mir-103a-2-5p ; hsa-mir-4772-5p ; hsa-mir-383-5p ; hsa-mir-2681-5p ; hsa-mir-1305 ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-431-5p ; hsa-mir-5093 ; hsa-mir-3682-3p ; hsa-mir-153-5p ; hsa-mir-651-3p ; hsa-mir-203a-3p ; hsa-mir-1277-5p ; hsa-mir-6083 ; hsa-mir-5696 ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-3941 ; hsa-mir-4729 ; hsa-mir-5011-5p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-5580-3p ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-1267/Downstream/383727;
Nearest TSS
ENST00000623511/Upstream/23532; ENST00000490152/Downstream/16527;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/90561, chr13-CpG: 24/Downstream/68334
Nearest cancer related gene
ZMYM2(OG, No orient, 0)
Upstream sequence
AAAGAAACCCTGGAACAATTCTATGGTTATTTCGAAGAACAGTCTCGCTGGTGAGAATTTAACAAAGGGACTTTTTTATTATTGAGTGAAAATATGATCT
Downstream sequence
TGGTTGATATTAAGTGCTATTGTTACTGAGATGATCACATAATACTATCAGCAGTATAAAATTTGGATTCACAAGTTTTTGGACAAGAGTTGTGATATTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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