Basic Information
VIS ID
TVIS44014825
Fusion event
HTLV-1-IDH3A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
78445624/78153282 (Hg38)
End
78445624/78153282 (Hg38)
Orient
+
Location type
Intronic
Target gene
IDH3A
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-7-5p ; hsa-mir-107 ; hsa-mir-4784 ; hsa-mir-103a-3p ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-7515 ; hsa-mir-1184 ; hsa-mir-922 ; hsa-mir-6847-5p ; hsa-mir-6760-5p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-4524b-3p ; hsa-mir-3154
Nearest miRNA
hsa-mir-10393/Upstream/2390967; hsa-mir-11181/Downstream/1056506;
Nearest TSS
ENST00000557528/Upstream/3873; ENST00000561366/Downstream/3641;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/3363, chr15-CpG: 103/Downstream/110781
Upstream sequence
agctcctgggctcaagcagtcctgagctcaagccgacttagcctcccatgtagctgagaccattggtgtgcaccaccatacctggctaattttgtagaga
Downstream sequence
cagggtctcactttgttgcacagcctggtTGGTTGGGTCTTCTGTCACAAGGACATGAGTTTTGTGTGAATGTCTTTTCCTTCTTTTTTGTTCAGGGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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