Basic Information
VIS ID
TVIS44014834
Fusion event
HTLV-1-TSHZ1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
72957328/75245373 (Hg38)
End
72957328/75245373 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSHZ1
miRNAs that regulate target gene
hsa-mir-1305 ; hsa-mir-498 ; hsa-mir-488-3p ; hsa-mir-4465 ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-1297 ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-6513-3p ; hsa-mir-5582-5p ; hsa-mir-5680 ; hsa-mir-548an ; hsa-mir-124-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2391991;
Nearest TSS
ENST00000575820/Upstream/797; ENST00000584217/Downstream/37491;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/33146, chr18-CpG: 28/Downstream/42322
Upstream sequence
TTTAGAAGTTGGATGCGGGAAATAGCCAGTGCCACCTGAAGCTGTGGAAACAAACAGGAGCTTGGACTTTGCAGGCATACCTCTTTTTAAAGTGAAGACA
Downstream sequence
TTTTCAGGAACCCCTGGATTTTTAAGGGTATGTCAGTGTTAATTTTTAACTATGTAATTGGTATTTTAAATATCTTTTTAGTTTGTACGATGCTGCTGTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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