Basic Information
VIS ID
TVIS44014847
Fusion event
HTLV-1-PPP4R1L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
56842978/58267922 (Hg38)
End
56842978/58267922 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
PPP4R1L
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-4539 ; hsa-mir-27b-5p ; hsa-mir-369-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/946331; hsa-mir-1-1/Downstream/549693;
Nearest TSS
ENST00000382410/Upstream/39269; ENST00000488949/Downstream/41774;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/38866, chr20-CpG: 81/Downstream/41388
Upstream sequence
CTCCACAGCCCCATAGCATGCAACAGGCAGCCTCATGAAACCAGACATCCAGCCTCCTGCCTTCTCCAGCTGCTACTCAGCACCCACAACCACACCTCTC
Downstream sequence
TGCTTAACTAGCAACTCACCCATACTTCACAGTGGGGGTGAACAAGAGGAAAGGAGATAAGCCAAGCTAGCCTGGAGCACAGCCCTGGAGCACAGCGACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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