Basic Information
VIS ID
TVIS44014870
Fusion event
HTLV-1-ATP10D integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p12
Reference genome
GRCh37/hg19
Start
47580546/47578529 (Hg38)
End
47580546/47578529 (Hg38)
Orient
-
Location type
Intronic
Target gene
ATP10D
miRNAs that regulate target gene
hsa-mir-192-5p ; hsa-mir-335-5p ; hsa-mir-493-3p ; hsa-mir-4452 ; hsa-mir-4780 ; hsa-mir-183-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p
Nearest miRNA
hsa-mir-12113/Upstream/7076410; hsa-mir-1243/Downstream/74140;
Nearest TSS
ENST00000502981/Upstream/217; ENST00000512393/Downstream/1870;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/114727, chr4-CpG: 18/Downstream/127897
Upstream sequence
TTCCCCTTTCAGGTTCCAGTGGACCCCGTGAGTTAATCCCTCCAGCCTCTCATTTATCTTAATCATGATCCTTCTCTCTTTACTTTTGTAAGTCCTATTC
Downstream sequence
CTCATGTGACTGTGGGAAATTGTATTTCTTTCCTTTTACTCTAGGTTCTTTGAGCAACCTCTCTCTCCCCAGATGCATGAAGTTATATTTTAACTTATCC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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