Basic Information
VIS ID
TVIS44014887
Fusion event
HTLV-1-TNFAIP8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
118669540/119333845 (Hg38)
End
118669540/119333845 (Hg38)
Orient
+
Location type
Intronic
Target gene
TNFAIP8
miRNAs that regulate target gene
hsa-mir-452-5p ; hsa-mir-574-5p ; hsa-mir-23c ; hsa-mir-23b-3p ; hsa-mir-23a-3p ; hsa-mir-130a-5p ; hsa-mir-6867-5p ; hsa-mir-223-5p ; hsa-mir-630 ; hsa-mir-4717-3p ; hsa-mir-147a ; hsa-mir-6818-5p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-92a-2-5p ; hsa-mir-654-5p ; hsa-mir-541-3p ; hsa-mir-6787-3p ; hsa-mir-6884-3p ; hsa-mir-3614-3p ; hsa-mir-9-5p ; hsa-mir-193b-5p ; hsa-mir-483-5p
Nearest miRNA
hsa-mir-10397/Upstream/179129; hsa-mir-103a-1/Downstream/9763843;
Nearest TSS
ENST00000502646/Upstream/670; ENST00000504642/Downstream/20469;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/64706, chr5-CpG: 42/Downstream/21861
Upstream sequence
GTGGCTTTAGAGCTACTGTGTTCAACAAATCACTGTTTTGTTTTGTTTTGCTATGGCTCTGGGTGTGGGGAACCAGTGTTAAGCAGGGAGAGGTATGAGT
Downstream sequence
ATTGTGGGTGGAAAAATGACATTTAAAGTTTGCATGTAGACAGTTTCATTTGTAAACAGATAAAGATTTGAAATGTTTCAGAGATGGGACTCTGAAAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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