Basic Information
VIS ID
TVIS44014894
Fusion event
HTLV-1-ICK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
52916359/53051561 (Hg38)
End
52916359/53051561 (Hg38)
Orient
-
Location type
Intronic
Target gene
ICK
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-101-3p ; hsa-mir-4760-3p ; hsa-mir-3942-3p ; hsa-mir-449c-3p ; hsa-mir-27b-3p ; hsa-mir-27a-3p ; hsa-mir-513a-5p ; hsa-mir-6825-5p ; hsa-mir-7106-5p ; hsa-mir-766-5p ; hsa-mir-6077 ; hsa-mir-8086 ; hsa-mir-6770-5p ; hsa-mir-3179 ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-205-3p ; hsa-mir-3154 ; hsa-mir-943 ; hsa-mir-4439 ; hsa-mir-3136-5p ; hsa-mir-6516-3p ; hsa-mir-3152-3p ; hsa-mir-205-5p ; hsa-mir-892a ; hsa-mir-6715b-3p ; hsa-mir-6715a-3p ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-10398/Upstream/902520; hsa-mir-10524/Downstream/225432;
Nearest TSS
ENST00000381078/Upstream/56183; ENST00000461222/Downstream/430;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/56592, chr6-CpG: 67/Downstream/9919
Upstream sequence
atccattctttgtctcttccagcttctggtggttgcaagcactccttggcttgtgaccacatcaccccagtctctgcctctatgatcacattttcttgtc
Downstream sequence
ttctgtttttaaatcttcctctgtctctagcttataaggacttgtgttttcatttaaggcctaccaagatactgcaggataatctctccatttccgattt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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